Supplement Stack
Every oral supplement, why it's there, and what it needs to actually absorb. Most supplements fail because the cofactors are missing. These don't.
The stack moved to a 16:8 intermittent fasting schedule. Last food ~7 PM, nothing until noon. This changed when everything is taken, not just what.
BPC-157 injection only. No food, no supplements. BPC-157 absorbs fine without food, so the fast stays unbroken.
Main meal — chicken or fish, super greens, nuts, chickpeas, fruit. Full supplement round taken after eating.
Smoothie with raw cacao. Second round: aspirin, resveratrol, Lion's Mane, red beet powder.
Blood thinner for DVT — active clots in both legs. Inhibits platelet aggregation and reduces clot propagation risk. Taken in place of ibuprofen, naproxen, and acetaminophen, which blunt the prostaglandin signaling that BPC-157 depends on for tissue repair.
Natural blood thinner important with DVT. Potent anti-inflammatory via prostaglandin pathway modulation. EPA+DHA support angiogenesis and nerve repair. The 720mg Omega-3 is the number that matters — not total fish oil weight.
Dietary nitrates → nitric oxide → vasodilation → increased blood flow to the ankle. One of the few oral supplements that measurably increases peripheral blood flow in the short term.
Collagen synthesis — every step of collagen production requires Vitamin C. The ankle wound cannot close without it. Rose hips add bioflavonoids that extend C's activity and bioavailability. Also preserves the nitric oxide produced by the beet powder.
Required for every stage of wound healing — from initial inflammation through proliferation and remodeling. Zinc drives keratinocyte migration (skin closure), immune cell activity at the wound, and collagen cross-linking. A wound that won't close almost always involves zinc deficiency.
Balances zinc. High-dose zinc (50mg) depletes copper over time because they compete for the same absorption transporter. Copper is also required for collagen cross-linking (lysyl oxidase enzyme) and angiogenesis — both directly relevant here.
Vasodilation, nerve function, muscle health, cofactor for 300+ enzymes. Glycinate is the best-absorbed form and least likely to cause GI issues. Critical for the neuropathy picture — magnesium is required for nerve signal conduction, and it's also what keeps supplemental potassium inside the cells.
Blood viscosity, circulation, electrolyte balance. With DVT and sluggish venous return, potassium helps maintain proper fluid pressure gradients in the vessels. The 16:8 fasting window also increases electrolyte turnover.
Nerve repair, energy metabolism, red blood cell production. B12 deficiency mimics and worsens neuropathy — the sublingual delivery bypasses stomach absorption issues entirely. B1 (thiamine) is critical for nerve function. Niacin (B3) supports cellular energy and vasodilation.
D3 activates wound healing genes and is required for magnesium to be transported properly. K2 (MK-7 form, 72-hour half-life) directs calcium away from arteries and into bone — critical with DVT and the clotting picture.
Added Week 4. Stimulates nerve growth factor (NGF) and brain-derived neurotrophic factor — the signals that drive peripheral nerve regeneration and remyelination. This is the most directly on-target addition for the neuropathy side of the picture, which BPC-157 was carrying alone.
Added Week 4. Sirtuin activator — it switches on the same repair pathways that NAD+ and NMN fuel. Also an antioxidant and mild vasodilator with some evidence for endothelial function, which matters with DVT.
NAD+ is required for every energy-producing reaction in the cell and for the sirtuin repair enzymes. As we age it declines. Cellular energy is the fuel for all the repair work being asked of the body — angiogenesis, collagen synthesis, nerve regeneration.
NAD+ precursor, running the same pathway from the other end. Raises cellular NAD+ and activates sirtuin repair pathways.
NMN and NAD+ supplementation depletes methyl groups over time. TMG donates the methyl groups that keep homocysteine in check. Without it, fatigue and elevated cardiovascular risk develop within weeks of running NMN + NAD+.
Cortisol reduction, stress response, anti-inflammatory adaptogen. Chronic stress elevates cortisol, which directly impairs wound healing by suppressing immune function and collagen synthesis. KSM-66 is the best-studied full-spectrum root extract.
The combinations that actually work — and why.
Nothing but the injection until noon. The extended fast lets autophagy run — the cellular clean-out that a first-thing breakfast shuts off. BPC-157 needs no food to absorb, so the fasted shot costs nothing and the window stays intact.
Lion's Mane raises nerve growth factor, B12 and thiamine supply the raw material for myelin repair, magnesium enables the nerve signal conduction itself. The one axis where the new stack is stronger than the old one.
All three required simultaneously for collagen synthesis and wound closure. C handles hydroxylation of proline, zinc drives cell proliferation, copper cross-links the collagen chains. Missing any one breaks the chain.
Dietary nitrates dilate vessels. Vitamin C prevents NO from oxidizing before it reaches the ankle. BPC-157 signals new vessel growth. Three mechanisms hitting blood flow simultaneously.
D3 is the gatekeeper — without it, magnesium can't be transported efficiently. B6 gets it into cells. Potassium stays in cells when magnesium is adequate. All four together or the chain breaks.
NMN and NAD+ raise cellular energy but drain methyl groups. TMG replenishes them. Resveratrol activates sirtuins that NAD+ fuels. Skip TMG and you'll feel the depletion within weeks.
The primary anti-inflammatory for the first three weeks, dropped in Week 4. Nothing in the new stack replaces its NF-κB suppression — Lion's Mane and resveratrol act on different pathways. If inflammatory pain returns, this is the most likely reason.
Simplified back to a single 1300mg KSM-66 product. A meaningful reduction in total daily adaptogen load.
Replaced by organic red beet powder capsules, 700mg × 3 twice daily. Same nitrate target, different product.
Eliminated with the move to 16:8 fasting on Sep 2. It was the fat cofactor for the fat-soluble supplements — that role has moved to the noon meal's fish and nuts, which covers it.